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When should I take Benadryl and cough syrup?

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Continue taking Benadryl with meals and at bedtime for the rest of the time you will be in a motion-sickness situation. As a sleep aid, take Benadryl within 30 minutes before bedtime. Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
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